Education
The development of paracetamol began with the discovery of the fever lowering effect of acetanilide, a founding that resulted in the development of phenacitin by Bayer.
Paracetamol, N-acetyl-p-aminophenol, was a derivative synthesized by Bayer’s chemists in 1888 by Bayer but never tested for medicinal properties.
In 1893, it was evaluated clinically by Dr. von Mering, Schmiedeberg’s former student, who found that the drug produced methemoglobinemia.
However he believed mistakenly that it produced methemoglobinemia as an adverse effect and the compound was ignored.
A century later, paracetamol was reinvestigated in the United States, at the University of Yale by David Lester and C. A Greenberg, who demonstrated that paracetamol was the major metabolite of acetanilide and phenacetin, and was relatively safe as an analgesic and antipyretic.
At the same time, Flinn and Brodie found that even at high oral doses, paracetamol is not attended by the formation of methemoglobin.
In 1950 the first paracetamol product – a combination of paracetamol, aspirin and caffeine was in the United States market under the name Triagesic.
Discovery of Paracetamol
- Food Irradiation In History
The generic term ‘irradiation’ appears in the literature only until the 1940s. Food irradiation history began when the discovery of x-ray by Roentgen in 1805 and radioactive substances by Becquerel in 1896. Following these discoveries there was much...
- Biography Of Waksman, Selman Abraham (1888 – 1973)
Russian born United States biochemist, Waksman won the 1952 Nobel Prize for Physiology or Medicine for his discovery of the antibiotic streptomycin. He was one of the world’s foremost authorities on soil microbiology. Waksman, Selman Abraham was born...
- Domagk, Gerhard (1895 – 1964)
Gerhard Johannes Paul Domagk German bacteriologist awarded the 1939 Nobel Prize for Physiology or Medicine for his discovery of antibacterial effects of Prontosil, the first sulphonamide drug. Born the son of a teacher in October 30, 1895, in Lagow in...
- Discovery Of Vitamin D
The first scientific description of a vitamin D-deficiency, namely rickets, was provided in the 17th century by both Dr. Daniel Whistler (1645) and Professor Francis Glisson (1650). The relationship between rickets and lack exposure to the sun was suspected...
- History Of Aspirin
From historical perspective, as early as about 3000 BC, aspirin in its crude form was known to the Egyptians, who employed the decoction of salicylates-containing plants like myrtle or willow leaves for joint pain. Hippocrates of Kos, around 500 BC, recommended...
Education
Discovery of Paracetamol
The development of paracetamol began with the discovery of the fever lowering effect of acetanilide, a founding that resulted in the development of phenacitin by Bayer.
Paracetamol, N-acetyl-p-aminophenol, was a derivative synthesized by Bayer’s chemists in 1888 by Bayer but never tested for medicinal properties.
In 1893, it was evaluated clinically by Dr. von Mering, Schmiedeberg’s former student, who found that the drug produced methemoglobinemia.
However he believed mistakenly that it produced methemoglobinemia as an adverse effect and the compound was ignored.
A century later, paracetamol was reinvestigated in the United States, at the University of Yale by David Lester and C. A Greenberg, who demonstrated that paracetamol was the major metabolite of acetanilide and phenacetin, and was relatively safe as an analgesic and antipyretic.
At the same time, Flinn and Brodie found that even at high oral doses, paracetamol is not attended by the formation of methemoglobin.
In 1950 the first paracetamol product – a combination of paracetamol, aspirin and caffeine was in the United States market under the name Triagesic.
Discovery of Paracetamol
- Food Irradiation In History
The generic term ‘irradiation’ appears in the literature only until the 1940s. Food irradiation history began when the discovery of x-ray by Roentgen in 1805 and radioactive substances by Becquerel in 1896. Following these discoveries there was much...
- Biography Of Waksman, Selman Abraham (1888 – 1973)
Russian born United States biochemist, Waksman won the 1952 Nobel Prize for Physiology or Medicine for his discovery of the antibiotic streptomycin. He was one of the world’s foremost authorities on soil microbiology. Waksman, Selman Abraham was born...
- Domagk, Gerhard (1895 – 1964)
Gerhard Johannes Paul Domagk German bacteriologist awarded the 1939 Nobel Prize for Physiology or Medicine for his discovery of antibacterial effects of Prontosil, the first sulphonamide drug. Born the son of a teacher in October 30, 1895, in Lagow in...
- Discovery Of Vitamin D
The first scientific description of a vitamin D-deficiency, namely rickets, was provided in the 17th century by both Dr. Daniel Whistler (1645) and Professor Francis Glisson (1650). The relationship between rickets and lack exposure to the sun was suspected...
- History Of Aspirin
From historical perspective, as early as about 3000 BC, aspirin in its crude form was known to the Egyptians, who employed the decoction of salicylates-containing plants like myrtle or willow leaves for joint pain. Hippocrates of Kos, around 500 BC, recommended...